相关实验视频
Updated: Jul 21, 2025
08:05
Isolation of Embryonic Ventricular Endothelial Cells
Published on: July 20, 2013
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胚胎发育期间内皮细胞原4α1表达的暂时受限模式,通过一种新型的诺金Col4a1-P2A-eGFP小鼠线确定
Nathaniel L Lartey1, Martijn van der Ent1, Roxann Alonzo1
1Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Genesis (New York, N.Y. : 2000)
|July 28, 2023
概括
第四类原蛋白对血管健康至关重要. 这项研究表明,内皮细胞在胚胎发育过程中积极合成IVα1原蛋白,在出生前的合成下降.
科学领域:
- 血管生物学 血管生物学
- 细胞外矩阵生物学 细胞外矩阵生物学
- 分子遗传学 分子遗传学
背景情况:
- 经典的IV型原蛋白,是原蛋白IVα1和α2链的异构分离体,由内皮细胞 (EC) 合成,形成血管底膜.
- 编码原IVα1/α2,氨酸受体B4 (EPHB4) 或RASA1的基因突变导致血管功能障碍,原因是原IV出口受损或信号通路改变.
- 了解EC对IV原蛋白的时间合成对于阐明IV原蛋白相关血管疾病的病原性至关重要.
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