诺基诺的长期毒性:一个全面的审查
Narmin Hama Amin Hussen1, Shnyar Hamid Qadir2, Heshu Sulaiman Rahman3,4
1Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, University of Sulaimani, Sulaimaniyah, Iraq.
Drug and chemical toxicology
|July 28, 2023
概括
诺基诺相关毒性 (FQAT) 包括长期的中枢神经系统 (CNS) 影响. 本综述详细介绍了FQ机制和相互作用,特别是NSAIDs和theophylline,影响中枢神经系统的安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
背景情况:
- 诺基诺 (FQs) 是一种广泛的杀菌抗生素.
- 美国食品和药物管理局已经注意到潜在的长期基诺相关毒性 (FQAT),包括中枢神经系统的影响.
- 目前还没有完全记录FQAT,需要对现有数据进行审查.
研究的目的:
- 审查关于长期诺基诺相关毒性 (FQAT) 的现有信息.
- 专注于FQs的中枢神经系统 (CNS) 毒性.
- 阐明FQ诱导的中枢神经系统毒性的机制,包括药物相互作用.
主要方法:
- 关于FQAT的文献综述,重点关注中枢神经系统的影响.
- 对中枢神经系统受体的FQ作用机制的分析.
- 药物相互作用的检查 (例如,FQ与NSAIDs,神素).
主要成果:
- 特定的FQs与非替代的7-piperazine和7-pyrrolidine R7侧链显示出显著的中枢神经系统影响.
- 已确定FQ诱导的中枢神经系统毒性的三个主要机制:直接的药理作用,药动力学相互作用 (例如FQ-NSAIDs) 和药动力学相互作用 (例如FQ-theophylline).
- 抑制胺黄油酸-A (GABAA) 受体是一个关键途径.
结论:
- 诺基诺可以导致显著的中枢神经系统长期毒性.
- 药物相互作用,特别是NSAIDs和theophylline,加剧FQ诱导的中枢神经系统影响.
- 了解这些机制对于管理FQAT和确保患者安全至关重要.
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