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"高增殖性形前列腺癌"定义了一个具有较差预后的患者亚组
Mari Bogaard1,2,3, Rolf I Skotheim2,4, Aase V Maltau2
1Department of Pathology, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.
Histopathology
|July 28, 2023
概括
前列腺癌患者的高Ki67水平与cribriform模式表明明显更高的复发风险. 这一发现支持将Ki67纳入常规病理学报告,以改善前列腺癌预后.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物研究 生物标志物研究
背景情况:
- 原发性前列腺癌 (PCa) 的预后依赖于各种生物标志物,包括cribriform模式,反应性树突 (RS),PTEN,Ki67和ERG.
- 前列腺癌风险评估术后 (CAPRA-S) 评分用于预测PCa结果.
- 了解这些因素的相对贡献对于完善预后模型至关重要.
研究的目的:
- 为了评估cribriform模式的独立和综合预测值,RS,PTEN,Ki67,ERG和CAPRA-S在原发性前列腺癌中的得分.
- 确定这些预后因素对预测生化复发 (BCR) 和临床复发 (CR) 的相对贡献.
- 确定针对性治疗策略的高风险患者子组.
主要方法:
- 对475名经过激进前列腺切除术的患者进行了回顾性分析.
- 评估cribriform模式,PTEN损失,ERG表达,RS,以及高Ki67.7的情况.
- 对PTEN和Ki67.7的内焦和间焦异质性的评估.
- 统计分析以确定BCR和CR的独立预测因子及其相对贡献,并使用CAPRA-S得分作为参考.
主要成果:
- 形形状 (57%) 和高Ki67 (9%) 是BCR和CR的独立预测因素.
- ERG表达 (51%) 独立预测了CR.
- Cribriform模式解释了11%的BCR变化,而Ki67解释了21%的CR变化.
- 患有cribriform模式和高Ki67的患者显示BCR (HR=2.83) 和CR (HR=4.35) 的风险明显更高.
结论:
- 一个cribriform模式和高Ki67的组合确定了一个高风险的"高增殖性cribriform前列腺癌"子组.
- 支持在病理学中报告cribriform模式.
- 建议在前列腺癌病理学中实施Ki67评估,以改善风险分层.
关键词:
在 ERG ERG 里面,有很多东西可以做.在 Ki6767 的位置上.在这里,我们可以使用PTEN.生物标志物生物标志物形形状的图案 形状的图案预后 预后 预后前列腺癌是前列腺癌.反应性流体反应性流体更多相关视频
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