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3D生物打印-一种用于皮肤衰老的模型

Ryeim B Ansaf1, Rachel Ziebart2, Hemanth Gudapati3

  • 1Department of Biology, Colorado State University Pueblo, Pueblo, CO 81001, USA.

Regenerative biomaterials
|July 28, 2023
PubMed
概括

随着人们的寿命越长,开发可靠的老年人皮肤模型对于药物测试至关重要. 三维生物打印提供了一个有前途的解决方案,用于创建功能性的老化皮肤等价物.

关键词:
在3D生物打印中使用3D生物打印老化的老化 衰老的老化生物墨水是生物墨水.复兴再生是一种再生方式.皮肤 皮肤 皮肤

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科学领域:

  • 再生医学是一种再生医学.
  • 生物技术是生物技术.
  • 皮肤病学 皮肤病学

背景情况:

  • 人类的寿命正在增加,导致与年龄相关的皮肤疾病的增加.
  • 目前用于药物测试的动物模型不能准确地复制人类皮肤反应.
  • 开发一个功能性的老年人皮肤模型是具有挑战性的,因为个体皮肤的变化.

研究的目的:

  • 为了回顾人类皮肤衰老的过程.
  • 使用3D生物打印概述了使用3D生物打印创建老化皮肤模型的概述.
  • 讨论当前生物打印皮肤模型和未来的研究方向.

主要方法:

  • 对人类皮肤衰老过程的审查.
  • 用于皮肤组织工程的3D生物打印技术的描述.
  • 利用皮肤细胞,如角质细胞,纤维细胞和黑色细胞.

主要成果:

  • 3D生物打印可以创建人体皮肤等价物.
  • 开发具有感觉,血管化和再生的功能性老化皮肤模型的潜力.
  • 鉴定了当前生物打印皮肤模型的局限性.

结论:

  • 3D生物打印是一种可行的技术,用于创建老化的人类皮肤模型.
  • 这些模型可以作为临床级的外科移植和药物测试.
  • 需要进一步的研究来克服局限性并增强生物打印皮肤的功能.