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消毒的Akkermansia muciniphila改善葡萄糖代谢,与下丘脑中氧化释放量的增加有关
Anne Abot1, Amandine Brochot2, Nicolas Pomié1
1Enterosys SAS, 31670, Labège, France.
在临床前的模型中,消毒的Akkermansia muciniphila改善了葡萄糖代谢和胰岛素敏感性. 这种有益的效果通过肠-大脑轴通过影响肠道运动性和下丘脑氧化释放来调解.
科学领域:
- 微生物学 微生物学
- 代谢性疾病研究研究.
- 神经科学是一个神经科学.
背景情况:
- 在临床前和人体研究中,巴氏杀菌的Akkermansia muciniphila显示出抗糖尿病特性.
- 肠道屏障功能是一个已知的机制,但A. muciniphila在通过肠-大脑轴控制葡萄糖的作用仍然未被探索.
- 调节肠道运动性为高血糖症提供了潜在的治疗策略.
研究的目的:
- 调查巴氏杀菌A. muciniphila对肠道运动,肠-大脑轴信号传输和葡萄糖代谢的影响.
- 探索A. muciniphila在管理高血糖症方面的一种新的作用机制.
主要方法:
- 给小鼠食高脂肪饮食 (HFD) 并用消毒的A. muciniphila Muc治疗了12周.
- 评估对体重,脂肪量,葡萄糖代谢 (胰岛素,血糖,耐葡萄糖),十二指肠收缩,肠部神经递质释放和下丘脑氧化 (NO) 释放的影响.
主要成果:
- 消毒A. muciniphila补充剂改善了HFD小鼠的代谢参数,包括体重,脂肪量,胰岛素水平,血糖和葡萄糖耐受性.
- 这些改善与十二指肠收缩减少和下丘脑NO释放增加相关.
结论:
- 消毒的A. muciniphila通过一种新的肠-大脑轴信号通路对代谢健康产生有益影响.
- 这项研究表明了一种新的机制,通过这种机制,A. muciniphila在2型糖尿病的临床前模型中影响血糖控制.
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