在非尿道分离物中预测扩展谱β-乳糖酶产生肠道细菌 (ESBLE) 感染的风险因素
Rachel Burgoon1, Aaron Hamby1, Erin Weeda2
1Department of Pharmacy, Medical University of South Carolina (MUSC) Health, Charleston, SC, USA.
概括
识别患有扩展谱β-乳糖酶产生肠杆菌 (ESBLE) 感染的高风险患者至关重要. 肝硬化,尿导管,中央静脉导管和ESBLE病史独立地与感染风险增加有关.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床医学 临床医学
背景情况:
- 抗微生物耐药性需要及时和适当的抗微生物治疗.
- 扩展光谱β-乳糖酶产生肠道细菌 (ESBLE) 构成了日益严重的全球健康威胁.
- 快速诊断并非所有人都可以使用,这凸显了识别耐药性风险因素的必要性.
研究的目的:
- 与非尿路ESBLE感染相比,确定与非尿路ESBLE感染相关的因素.
- 在临床环境中分析ESBLE感染的风险因素.
主要方法:
- 患者培养物 (血液,细菌,排泄物) 的回顾性病例控制分析.
- 随机选择培养物以获得ESBLE与非ESBLE感染的1:1比.
- 收集基线人口统计数据和风险因素,包括恶性瘤,肝硬化,AKI和糖尿病.
主要成果:
- 单变量分析发现肝硬化,AKI,尿导管,中央静脉导管,以前的ESBLE感染,医院获得的感染和最近的抗生素使用是显著的.
- 多变量分析揭示了与ESBLE相关的四个独立因素:肝硬化,尿导管,中央静脉导管和ESBLE病史.
- 患有ESBLE感染的病史显示了ESBLE感染的最高调整几率比率 (aOR 12.49).
结论:
- 将已识别的风险因素纳入临床决策支持工具可以帮助识别高风险患者.
- 这些发现有助于主动管理和针对ESBLE感染的有针对性的干预措施.
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