以便为基础的结肠直肠癌查测试在有和没有的人中的性能特征
Derek W Ebner1, David Rushlow2, Joshua Mou3
1Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
并不会影响结肠直肠癌查测试,如FIT和多目标便DNA. 这些非侵入性便检测仍然有效用于CRC查,即使是无症状.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 诊断医学 诊断医学
背景情况:
- 结肠直肠癌 (CRC) 查依赖于非侵入性便测试.
- 很常见,可能会影响测试的准确性.
- 对CRC查测试评估的影响至关重要.
研究的目的:
- 评估出血对便免疫化学测试 (FIT) 和多目标便DNA (mt-sDNA) 查CRC的表现的影响.
主要方法:
- 追溯队列研究分析测试特征 (灵敏度,特异性,预测值).
- 患者根据在结肠镜检查期间记录的状况进行了分层.
- 在患有和没有的患者之间比较了FIT和mt-sDNA的性能.
主要成果:
- 在51.7%的队列中存在.
- 根据状况,没有观察到FIT或mt-sDNA表现的统计学上显著差异.
- 无论是否存在,FIT和mt-sDNA的敏感性和特异性都保持了可比性.
结论:
- 无症状并不会对FIT和mt-sDNA用于CRC查的性能产生负面影响.
- 在没有明显出血的情况下,FIT和mt-sDNA是CRC查的可靠选择,不管状况如何.
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