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血清胆氨酶作为一种新的营养指标,用于预测患者的断奶失败
Jiaping Liu1, Tianyu Shao2, Hanwen Chen1
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Frontiers in medicine
|July 28, 2023
概括
较低的血清胆酶 (SCHE) 水平预测机械通风断奶失败. SCHE度,心率和PaO2一起,是关键预测因素,表明营养不良可能导致断奶困难.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 临床化学 临床化学
背景情况:
- 侵入性机械通风 (IMV) 是呼吸衰竭的关键支持措施.
- 预测IMV的成功断奶对于患者的康复和资源管理至关重要.
- 血清胆酶 (SCHE) 是一种与营养状况和器官功能相关的潜在生物标志物.
研究的目的:
- 调查血清胆酶 (SCHE) 水平与IMV患者断奶失败之间的关联.
- 为了确定通风机断奶失败的预测因素,包括SCHE.
- 探索SCHE,营养风险和断奶结果之间的关系.
主要方法:
- 对227名接受IMV治疗超过48小时的患者进行了回顾性观察性研究.
- 在自发呼吸试验 (SBT) 之前对SCHE度和临床数据的分析.
- 多因素后勤回归和倾向得分匹配被用来确定断奶失败的预测因素.
主要成果:
- 成功断奶的患者的SCHE水平明显高 (4,514 u/l),与断奶失败的患者 (3,190 u/l) 相比.
- 低于3,228 u/l的SCHE度是预测断奶失败 (AUC 0.714) 的关键值.
- SCHE,心率和PaO2是断奶失败的独立预测指标;在倾向得分匹配后,SCHE仍然显著.
结论:
- 较低的SCHE水平与因IMV而导致断奶失败的风险增加有关.
- SCHE作为一个有价值的独立预测断奶成功的预测器,与心率和PaO2.
- 研究结果表明,低SCHE表示的营养不良可能是断奶失败的重要因素,在尝试断奶之前,需要对低SCHE患者进行仔细评估.
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