剪切波弹性图用于评估慢性病毒性乙型肝炎和C型肝炎肝硬度
Diana Martonik1, Alicja Wandałowicz2, Łukasz Supronowicz1,2
1Medical University of Bialystok, Bialystok, Poland.
Clinical and experimental hepatology
|July 28, 2023
概括
二维剪切波弹性图 (2D-SWE) 准确地评估慢性乙型肝炎 (HBV) 和型肝炎 (HCV) 患者的肝纤维化. 肝活检的一致性很高,特别是在活检后24个月内.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 诊断技术 诊断技术
背景情况:
- 慢性乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 感染可能导致肝纤维化.
- 准确评估肝纤维化对于患者的管理和治疗决策至关重要.
- 肝活检仍然是黄金标准,但具有侵入性;人们正在寻求非侵入性方法.
研究的目的:
- 评估2D剪波弹性图 (2D-SWE) 硬度测量和慢性HBV和HCV患者肝活检结果之间的一致性.
- 在这些患者群体中评估2D-SWE和过渡性弹性体 (TE) 之间的一致性.
主要方法:
- 一项涉及153名慢性HBV (n=51) 和HCV (n=102) 患者的研究比较了2D-SWE硬度与肝活检结果.
- 在43名患者中,2D-SWE和TE (纤维素扫描) 在同一天进行.
- 使用统计分析来确定相关性和一致性.
主要成果:
- 在2D-SWE硬度和肝纤维化阶段之间发现了显著的正相关性 (r=0.555,p<0.001).
- 在24个月内进行时,2D-SWE和肝活检之间的一致性为96%,在24个月后降至81%.
- 在2D-SWE和TE之间观察到高连贯性 (r=0.872,p<0.001) 和一致性 (95%).
结论:
- 2D-SWE在HBV和HCV患者的肝活检中显示出与肝纤维化病阶段的良好一致性.
- 在HCV患者和在活检后24个月内进行2D-SWE时,一致性特别强.
- 2D-SWE是一种可靠的非侵入性工具,用于评估慢性病毒性肝炎中的肝纤维化.
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