使用NIH工具箱和PROMIS,量化COVID-19 (PASC) 后急性后续的神经精神病症状
Meghann C Ryan1, Huajun Liang2, Eleanor Wilson3
1Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
NeuroImmune pharmacology and therapeutics
|July 28, 2023
概括
与对照人群相比,患有COVID-19 (PASC) 后急性后续症的个人经历了较差的情绪健康和运动功能,但没有认知缺陷. 随着时间的推移,症状有所改善,这凸显了需要心理健康支持的需要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 后急性后续COVID-19 (PASC) 呈现出各种神经精神疾病症状.
- 量化这些症状对于了解COVID-19的长期影响至关重要.
- 需要标准化的评估工具来评估PASC相关的功能障碍.
研究的目的:
- 在PASC中使用NIH工具箱 (NIHTB) 和PROMIS量化神经精神症状.
- 为了比较PASC患者和对照者的神经和行为功能.
- 为了调查症状严重程度和COVID-19诊断后的时间之间的关系.
主要方法:
- 30名PASC和27名对照参与者完成了NIHTB和PROMIS评估.
- 协差分析 (ANCOVA) 对T分数的组差异进行了比较.
- 科恩的d效应大小和线性回归分析了随着时间的推移症状的进展.
主要成果:
- 与对照组相比,PASC患者的情绪健康和运动功能 (运动,耐力,灵敏度) 较差.
- 认知功能在各组之间仍然可比.
- 随着诊断后时间的增加,认知和运动测试得分的改善被观察到.
结论:
- 在PASC中,NIHTB和PROMIS有效地发现了情绪和运动缺陷.
- 正常的认知表现可能表明亚临床效应或补偿机制.
- 持续的症状强调了必须优先考虑PASC患者的心理健康治疗的必要性.
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