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Updated: Jul 21, 2025

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单细胞参考映射用于构建和扩展细胞类型层次结构

Lieke Michielsen1,2,3, Mohammad Lotfollahi4,5, Daniel Strobl4,6

  • 1Department of Human Genetics, Leiden University Medical Center, 2333ZC Leiden, The Netherlands.

NAR genomics and bioinformatics
|July 28, 2023
PubMed
概括

整合单细胞基因组学数据集需要协调细胞类型注释. 我们的treeArches框架构建了具有层次细胞注释的动态参考地图,使得共识和发现新的细胞状态成为可能.

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Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
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