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冠状动脉支架中血小板功能的周围过程变化:使用VerifyNow进行分析

Masataka Yoshimura^1,2, Kazutaka Sumita³, Shoko Fujii³

¹Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.

Journal of neuroendovascular therapy

|July 28, 2023

概括

在 carotid 动脉支架 (CAS) 后进行血小板功能测试至关重要. 虽然阿司匹林反应单位 (ARU) 保持稳定,但P2Y12反应单位 (PRU) 在CAS后大幅波动,表明血小板抑制发生了变化.

科学领域:

心脏病学心脏病学
血管外科血管外科
临床药理学临床药理学

背景情况:

血小板功能评估对于治疗双抗血小板治疗 (DAPT) 患者的并发症管理至关重要.
动脉支架 (CAS) 需要仔细监测抗血小板疗效,以防止不良事件.

研究的目的:

通过使用VerifyNow测试,研究CAS后血小板功能时间依赖的变化.
评估阿司匹林反应单元 (ARU) 和P2Y12反应单元 (PRU) 在不同时间点的价值.

主要方法:

在DAPT上接受CAS的43名患者的回顾性分析.
在前一天和CAS后的1,3,7天测量ARU和PRU.
统计比较ARU和PRU值,评估低反应率和高反应率.

主要成果:

阿司匹林反应单位 (ARU) 没有显著的时间依赖变化 (p=0.11).
P2Y12反应单位 (PRU) 呈现显著波动:在第1天升高 (中位数为233),然后在第7天下降至治疗范围 (中位数为51).
对PRU的低反应率在第1天显著增加 (51.2%) 和超反应率在第7天增加 (62.8%) (p<0.001两者).

结论:

血小板功能,特别是P2Y12抑制,在CAS后显示出显著的时间依赖变化.
在CAS后的早期,PRU水平可能超过治疗目标,并在第7天下降,因此需要谨慎监测.

关键词:

验证现在的验证.冠状动脉支架冠状动脉支架血小板功能血小板功能

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