伴随性焦虑对注意力缺陷/多动障碍儿童定量EEG异质性的影响

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Updated: Jul 21, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

15.8K

Changwon Jang¹, Soowhan Oh², Hyerin Lee¹

¹Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea.

Frontiers in psychiatry

|July 28, 2023

概括

患有注意力缺陷/多动障碍 (ADHD) 和并发性焦虑障碍的儿童表现出明显的定量脑电图 (Q-EEG) 模式,包括较低的太功率和较高的β功率. 这些Q-EEG差异突出了焦虑对ADHD异质性的影响.

科学领域:

神经科学是一个神经科学.
儿童精神病学儿童精神病学
定量脑电图 (Q-EEG) 是一种量子脑电图.

背景情况:

注意缺陷/多动障碍 (ADHD) 是一种常见的神经发育障碍.
伴随性焦虑症经常发生在患有多动症的儿童中,可能会影响临床表现和神经生理学标记.
定量脑电图 (Q-EEG) 提供了对脑活动的客观测量,可以区分ADHD亚型和并发症.

研究的目的:

为了比较仅患有ADHD的儿童和患有ADHD和并发性焦虑症的儿童之间的Q-EEG特征.
研究伴随性焦虑对ADHD儿童Q-EEG发现异质性的影响.
在诊断组中探索Q-EEG相对功率和/β比率 (TBR) 的差异.

主要方法:

评估了三个组:没有焦虑的多动症 (ADHD-Only,n=141),有焦虑的多动症 (ADHD-ANX,n=25) 和对照组 (n=43).
使用ANCOVA来比较Q-EEG相对功率和TBR,控制年龄,性别和FSIQ.
在ADHD参与者中使用集群分析来检查焦虑对Q-EEG异质性的影响.

主要成果:

在两组之间的theta和beta功率中发现了显著的差异,ADHD-ANX显示出比ADHD-Only更高的beta功率和更低的TBR.
对照组在这些Q-EEG测量中与ADHD组没有显著差异.
集群分析显示,在已识别的Q-EEG集群中,患有焦虑并发症的儿童比例存在显著差异.

结论:

患有多动症和并发性焦虑症的儿童表现出明显的Q-EEG概况,其特点是较低的中央乙太功率,更高的广泛乙太功率和较低的乙太/乙太比率.
伴随性焦虑在ADHD中观察到的Q-EEG特征的异质性中起着显著的作用.
Q-EEG测量可以帮助根据焦虑伴随性疾病的存在来划分ADHD人口中的子组.

关键词:

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