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电治疗后自杀倾向的减少与抑郁患者的前脑活动增加有关:休息状态fMRI研究

Xue Wang^1,2, Han Wu^1,2, Dan Wang^1,2

¹Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Frontiers in psychiatry

|July 28, 2023

概括

电疗法 (ECT) 可以通过改变大脑功能来治疗抑郁症中的自杀倾向. 具体来说,在ECT后,左上额头 (SFG) 和轨道额头皮层 (OFC) 的变化与自杀念头的减少相关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
放射学放射学是一门学科.

背景情况:

自杀倾向是抑郁症发作中的严重症状.
电疗法 (ECT) 是抑郁症的有效治疗方法,但其减少自杀倾向的机制尚不清楚.
休息状态功能磁共振成像 (rs-fMRI) 可以揭示大脑功能变化.

研究的目的:

为了研究使用rs-fMRI在ECT前后自杀倾向的抑郁患者的脑功能变化.
探索ECT在治疗自杀倾向方面的有效性背后的神经机制.

主要方法:

26名有自杀倾向的抑郁患者在基线和ECT后接受了rs-fMRI.
为了进行比较,包括了32个健康对照 (HC).
rs-fMRI测量包括低频波动的幅度 (ALFF),低频波动的分数幅度 (fALFF) 和区域均性 (ReHo).
临床症状使用汉密尔顿抑郁量表 (HAMD-17) 和贝克自杀念头量表 (BSSI) 进行评估.

主要成果:

在患者和HC之间观察到ALFF,fALFF和ReHo的基线差异.
在ECT后,患者在左上额头 (SFG) 和轨道额头皮层 (OFC) 中增加了fALFF.
左侧SFG和OFC中fALFF的增加与BSSI得分的降低相反相关,表明与自杀念头减少的联系.

结论:

左侧的SFG和OFC与ECT对自杀倾向的治疗效果有关.
左侧SFG和OFC内FALFF的变化可能代表了ECT减轻抑郁患者自杀念头的关键机制.

关键词:

患有抑郁症的患者.电疗法是一种电疗法.额头区域的前部区域.功能性核磁共振成像 (MRI) 功能性核磁共振成像自杀倾向自杀倾向自杀倾向自杀倾向

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