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Updated: Jul 21, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

嵌入式形象性磁盘增强剂的活性是通过染色质和自我调节在表观遗传上调节的

Yuzhong Cheng¹, Fountane Chan¹, Judith A Kassis¹

¹Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

bioRxiv : the preprint server for biology

|July 28, 2023

概括

嵌入的基因 (en)

科学领域:

发展生物学发展生物学
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

嵌入的基因编码了一种转录因子,这种转录因子对Drosophila发育至关重要.
增强剂以特定的空间和时间模式调节表达.
在小的记者转基因中,En的虚盘增强剂 (IDE) 不能正确运作.

结论:

在整个成像盘中,IDE刺激表达.
表观遗传调节器决定了ON/OFF状态的表达.
内源性 en locus 通过远程表观遗传影响提供功能稳定性.

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