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Updated: Jul 21, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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在多祖先表观基因组范围的分析中,在TOPMed MESA中确定了与大动脉增大指数相关的甲基化位点

Ani Manichaikul1, Xiaowei Hu2, Jeongok Logan2

  • 1University of Virginia School of Medicine.

Research square
|July 28, 2023
PubMed
概括

这项研究揭示了与动脉硬 (AS) 和脉动性血动力学 (PH) 相关的DNA甲基化模式. 像ETS1和HLA-DPB1这样的关键基因可能作为AS/PH的生物标志物,提供潜在的治疗点.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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