周心肥胖的心血管影响和遗传学
Joel T Rämö1,2,3, Shinwan Kany1,2,4, Cody R Hou1,5
1Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
medRxiv : the preprint server for health sciences
|July 28, 2023
概括
周心脂肪组织 (PAT) 与心血管疾病和2型糖尿病有关. 遗传分析揭示了与腹部脂肪的共同决定因素,突出了PAT作为一个独立的预测因素.
科学领域:
- 心血管疾病研究研究
- 遗传学和基因组学 在
- 医学成像分析 医学成像分析
背景情况:
- 以前对心周脂肪组织 (PAT) 和心血管疾病的研究受到样本大小和人口选择的限制.
- 心周脂肪组织 (PAT) 的遗传基础在很大程度上仍未被探索.
- 需要进行大规模的人口研究,以了解PAT在心血管健康中的作用.
研究的目的:
- 评估心周脂肪组织 (PAT) 与流行和发病心血管疾病之间的关联.
- 在大型队列中识别心周脂肪组织 (PAT) 的遗传决定因素.
- 探索PAT,心血管疾病风险和遗传因素之间的关系.
主要方法:
- 一个深度学习模型从英国生物银行心脏MRI扫描中量化了心周脂肪组织 (PAT).
- 分析了PAT与心血管疾病的截面和前性关联,控制共变量.
- 全基因组关联研究 (GWAS) 和多基因评分 (PGS) 分析在英国生物银行和FinnGen队列中进行.
主要成果:
- 周心脂肪组织 (PAT) 与年龄,BMI和腰部和部的比率有正相关,在男性中更高.
- 升高的PAT与患有心力衰竭,2型糖尿病,冠状动脉疾病和心房动有关.
- PAT预测发生心力衰竭和2型糖尿病独立于BMI,确定了5个新的遗传位点.
结论:
- 周心脂肪组织 (PAT) 与腹部脂肪具有共同的遗传决定因素.
- 周心脂肪组织 (PAT) 是发生2型糖尿病和心力衰竭的独立预测因素.
- 对PAT的遗传洞察力可能为心血管疾病的预防和治疗提供新的途径.
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