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每日人工重力部分缓解与头向下倾斜床相关的静脉处理变化

Rachael Seidler¹, Grant Tays¹, Kathleen Hupfeld¹

¹University of Florida.

Research square

|July 28, 2023

概括

人工引力 (AG) 可能会抵消从头向下倾斜床靠 (HDT) 的大脑变化. 与对照组不同,Daily AG防止了小脑激活的改变,并保持了平衡性能. 这表明AG可以减轻前庭处理变化.

科学领域:

神经科学是一个神经科学.
空间生理学空间生理学

背景情况:

微重力通过改变前体信号和减少身体负荷来诱导感官重量和适应.
头向下倾斜的床靠 (HDT) 模拟了这些卸载效应,人工重力 (AG) 是一种潜在的对策.
了解AG在缓解HDT诱导的生理变化的有效性对于太空飞行和康复至关重要.

研究的目的:

研究每天30分钟人工引力 (AG) 作为对抗60天头向下倾斜床靠 (HDT) 诱导的大脑和行为变化的对策.
通过功能磁共振成像 (fMRI) 评估AG在HDT期间对前庭处理和大脑激活模式的影响.

主要方法:

参与者接受了60天的HDT,其中一组每天接受30分钟的AG (AG组,n=16) 和对照组 (CTRL组,n=8) 不接受AG.
在HDT之前,期间 (两次) 和之后获得fMRI扫描,以测量前体刺激期间的大脑激活.
分析侧重于10个感兴趣的区域 (ROI),包括小脑,并包括探索性全脑分析.

主要成果:

在前体刺激期间,AG组没有显示小脑激活的变化,而CTRL组显示在HDT期间小脑激活的减少.
在AG组左OP2激活的减少变化与HDT后更好的平衡性能相关.
探索性分析显示,在HDT期间,CTRL组的右前中部和下部前部回旋的激活增加,在AG组保持在HDT前的水平.

结论:

人工引力可以减轻与头向下倾斜的床相关的前庭处理中的神经可塑性变化.
AG可能会保留大脑激活模式,从而在长时间卸载后改善平衡性能.
这些发现支持AG作为太空飞行和床研究的有希望的对策.

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