发展性语言障碍儿童大脑骨的微观结构性质
Salomi S Asaridou1, Gabriel J Cler1,2, Anna Wiedemann1,3
1Department of Experimental Psychology, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
bioRxiv : the preprint server for biology
|July 28, 2023
概括
患有发育性语言障碍 (DLD) 的儿童在小脑下部脚中表现出被破坏的白质连接,这表明小脑下层系统.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 发育神经科学的发展神经科学.
- 语音和语言科学 语言科学
背景情况:
- 发育性语言障碍 (DLD) 在没有明显原因的情况下影响母语学习.
- 神经生物学研究主要集中在皮层-层系统上,忽视小脑的作用.
- 小脑电路与感官运动学习有关,包括口语语言的学习.
研究的目的:
- 为了研究小脑白质道在患有DLD的儿童中的作用.
- 为了比较典型发育的儿童和DLD儿童之间的小脑脚微观结构.
- 为了确定DLD是否与非典型的皮质大脑或橄大脑连接有关.
主要方法:
- 在77名典型发育的儿童和54名患有DLD的儿童身上使用了扩散权重成像和概率曲谱.
- 分析了下部,中部和上部小脑脚.
- 量化了微结构性质 (分数异构,轴向扩散性,方向分散,神经质密度).
主要成果:
- 患有DLD的儿童在下大脑脚 (ICP) 中表现出较低的分数异构 (FA),表明轴突组织受损.
- 在ICP中减少的FA与更高的定向分散有关,但没有改变神经元密度.
- 在小脑中部和上部脚之间,没有发现群体之间的显著差异.
结论:
- 非典型的橄脑小白质连接,特别是在ICP中,是DLD的特征.
- 这些发现表明,在语音获取和DLD.LD.中涉及的是橄大脑小脑系统,而不是皮质大脑小脑电路.
- 在这个队列中,ICP微观结构的改变与语言或运动协调性能没有直接相关.
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