非线性多元体是行为过程中神经群体活动的基础
Cátia Fortunato1, Jorge Bennasar-Vázquez1, Junchol Park2
1Department of Bioengineering, Imperial College London, London UK.
bioRxiv : the preprint server for biology
|July 28, 2023
概括
神经群体活动,以前建模为平面,本质上是非线性的. 这种非线性,对于复杂的行为至关重要,大脑区域各不相同,并受到神经回路连接的影响.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 在行为过程中单个神经元的活动表现出高度多样性.
- 神经群体活动通常使用低维模型进行简化,假设是线性关系.
- 现有的模型将神经人口活动限制在一个平坦的"神经多元体"上.
研究的目的:
- 调查神经多元体是否本质上是非线性的.
- 为了确定任务复杂性如何影响神经多重非线性.
- 探索不同大脑区域的多重非线性变异.
主要方法:
- 从子,小鼠和人类运动皮层以及小鼠条纹体中记录了神经群体的活动.
- 应用了缩小维度的技术来分析神经群体结构.
- 利用循环神经网络模型来模拟电路连接和多重属性.
主要成果:
- 发现神经多元体在物种和大脑区域之间本质上是非线性的.
- 在复杂的行为任务中,非线性加剧,需要更多样化的神经活动.
- 在结构上不同的大脑区域中观察到多重非线性存在显著差异.
结论:
- 行为生成的基础的神经多元体本质上是非线性的.
- 考虑非线性对于理解复杂的自然行为至关重要.
- 电路连接在塑造大脑区域的多重非线性方面发挥着关键作用.
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