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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

812
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
812

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相关实验视频

Updated: Jul 21, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

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替代品选择总样 扩大T细胞克隆型

Peng Yu1, Yumin Lian2, Cindy L Zuleger3,4

  • 1Department of Statistics, University of Wisconsin, Madison.

bioRxiv : the preprint server for biology
|July 28, 2023
PubMed
概括
此摘要是机器生成的。

适应性免疫系统细胞种群的建模可以揭示选择试验如何丰富与疾病相关的克隆. 这项研究引入了一个新的统计框架来分析免疫学数据中的克隆扩张和基因组变化.

关键词:
贝叶斯规则就是贝叶斯规则.尤尔-西蒙定律是什么意思克隆扩张的扩张.多样性统计数据 多样性统计数据通过缩进行缩.可交换的出生-死亡过程.实验设计 实验设计一个单细胞测序.尺寸偏差是指大小偏差.身体突变是一种体质突变.

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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14:29

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 统计遗传学 统计遗传学

背景情况:

  • 适应性免疫系统细胞群体表现出克隆变异.
  • 了解克隆亚种群动态对于免疫学数据推断至关重要.
  • 替代品选择试验可能无意中为特定的细胞克隆进行丰富.

研究的目的:

  • 为适应性免疫中克隆子群体大小开发统计建模规范.
  • 量化代孕选择试验对T细胞克隆放大的影响.
  • 探索与克隆扩张相关的体质基因组改变的新统计措施.

主要方法:

  • 将克隆型内的出生死亡过程与跨克隆型的可交换模型结合起来.
  • 开发一个统计框架来分析免疫信息库数据.
  • 检查多样性统计和体内基因组改变的采样特性.

主要成果:

  • 证实了代孕选择试验可以丰富放大,可能与疾病相关的T细胞克隆.
  • 开发的框架允许研究多样性统计的抽样性质.
  • 确定了用于测量扩展克隆体内基因组改变负担的新统计数据.

结论:

  • 结合模型规范为分析免疫学样本提供了一个强大的框架.
  • 描述了在黑色素瘤替代品选择和单细胞基因组研究中T细胞谱的应用.
  • 增强对适应性免疫系统中的克隆动态和选择压力的理解.