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混合金属暴露对中部叶MRI扩散特征的影响
Eun-Young Lee1, Juhee Kim1, Janina Manzieri Prado-Rico2
1Department of Health Care and Science, Dong-A University, Busan, South-Korea.
medRxiv : the preprint server for health sciences
|July 28, 2023
概括
环境金属混合物与神经退行性疾病有关. 这项研究发现,混合金属暴露会影响大脑结构和认知功能,可能增加阿尔茨海默氏症.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 放射学 放射学是一门学科.
背景情况:
- 对金属混合物的环境暴露是常见的.
- 这种暴露可能会增加神经退行性疾病的风险,包括阿尔茨海默病.
研究的目的:
- 检查混合金属暴露与中叶MTLMRI结构指标之间的关联.
- 为了研究混合金属暴露对神经心理表现的影响.
主要方法:
- 评估金属暴露史和接烟雾暴露的受试者和对照者的全血金属水平.
- 使用形态学和扩散张力成像 (DTI) 度量评估了MTL结构.
- 使用相关性,回归和调解分析来检查金属对MTL结构和认知的影响.
主要成果:
- 暴露对象的血液中几个金属 (Cu,Fe,K,Mn,Pb,Se,Zn) 的含量较高,处理速度,执行和视觉空间领域的表现较差.
- 暴露对象在MTL区域显示了改变的DTI指标 (较高的MD,AD,RD;较低的FA),但没有形态差异.
- 混合金属暴露间接预测通过降低的副海马体分数异位性 (FA) 来降低处理速度.
结论:
- 混合金属暴露与MTL的结构和认知变化有关,类似于阿尔茨海默病风险人群的结构和认知变化.
- 这些发现表明,从环境金属暴露到阿尔茨海默病相关结果的潜在途径.
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