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相关概念视频

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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Measuring Near Plasma Membrane and Global Intracellular Calcium Dynamics in Astrocytes
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一个空间值为天体细胞激增的门.

Justin Lines, Andres Baraibar, Carmen Nanclares

    bioRxiv : the preprint server for biology
    |July 28, 2023
    PubMed
    概括

    天体细胞表现出信号传播的空间值. 超过这个值会引发的激增,影响脑中的神经递质释放和突触调节.

    科学领域:

    • 神经科学是一个神经科学.
    • 细胞生物学 细胞生物学
    • 天星细胞生物学 天星细胞生物学

    背景情况:

    • 星体细胞通过与神经元的双向通信在大脑功能中发挥关键作用,星体细胞的信号传递至关重要.
    • 星体细胞的信号可以局部化或在整个细胞中传播 (激增),可能通过转移体释放来调节突触.
    • 天体细胞信号的空间动态及其对神经调节的影响仍然不太清楚.

    研究的目的:

    • 调查控制天体细胞细胞内信号空间动态的特性.
    • 为了确定局部信号在全天体细胞中传播的条件.
    • 阐明天体细胞信号在调节神经转移和突触活动中的作用.

    主要方法:

    • 在感官刺激过程中,在小鼠皮质中的亚细胞质细胞反应的体内成像.
    • 使用转基因小鼠 (IP小鼠) 来研究2型IP3受体的作用.
    • 在现场电生理记录以评估质传递体释放.

    主要成果:

    • 传感唤起的天体细胞反应最初保持局部化,但在超过空间值 (>23%的树木化激活) 时传播到整个细胞.
    • 鉴定出2型IP3受体对于产生星细胞激增至关重要.
    • 研究人员发现,信号传播的空间值与神经递质释放之间存在直接的相关性.

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    Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators
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    Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

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    Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
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    Published on: November 19, 2014

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    结论:

    • 一个基本的空间值控制着星细胞细胞内信号的传播.
    • 这一门取决于天体细胞的内在特性,并决定了天体细胞对突触活动的整合.
    • 空间值控制着质递质的释放,从而调节了星细胞突触神经调节的范围.