发育中的人类大脑中的R环景观与神经分化和细胞类型特定的转录有关
Elizabeth A LaMarca1,2,3,4,5, Atsushi Saito6, Amara Plaza-Jennings1,2,5
1Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
bioRxiv : the preprint server for biology
|July 28, 2023
概括
R环,DNA/RNA结构,在产前人类大脑中是丰富的. 它们的调节影响神经前代细胞分化和神经发育基因表达.
科学领域:
- 基因组学就是基因组学.
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- R环是参与基因调节的三链核酸结构.
- 了解R循环动态对于理解大脑发育至关重要.
研究的目的:
- 为了绘制人类产前大脑中的R循环.
- 研究R环在神经前体细胞分化和神经发育中的作用.
主要方法:
- 人类产前大脑区域R环的基因组规模映射.
- 通过RNase H1的操纵,改变神经前中的R循环水平.
- 转录组分析和评估神经元连接.
主要成果:
- 在生殖基质中,R环非常丰富,特别是在差异化上调基因的促进者中.
- 减少神经祖先中的R循环促进了神经元的分化.
- 改变的R环水平影响了基因表达和神经元连接.
结论:
- 在神经前细胞分化过程中,R环在微调基因表达中起着至关重要的作用.
- R环是神经发育过程的重要调节者.
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相关概念视频
01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...