查对结肠直肠癌亚站点按年龄分布的影响
medRxiv : the preprint server for health sciences
|July 28, 2023
概括
灵活的半导体镜可检测大多数结直肠癌 (CRC),特别是在年轻人中. 这使得它成为切实可行的查替代结肠镜检查,以减少CRC死亡率.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 预防医学 预防医学
背景情况:
- 结肠镜在减少结肠直肠癌 (CRC) 死亡率方面的有效性是从队列研究中推断出来的,缺乏随机对照试验 (RCT) 数据.
- 灵活的半导体显微镜,支持RCT数据,为CRC查提供了一个潜在的更简单的实施方案.
研究的目的:
- 通过灵活的西格莫多斯科普来确定CRC病例的比例,通过灵活的西格莫多斯科普来解剖可见.
- 为了比较灵活的西格莫显微镜与结肠镜在CRC查中的有效性.
主要方法:
- 从监测,流行病学和最终结果计划 (2000-2020) 中分析结直肠腺癌病例.
- 基于可见性的瘤位置的分类,通过西格莫视镜与结肠镜对比.
- 根据年龄,阶段和瘤位置分层的限制平均生存时间 (RMST) 评估差异性预后.
主要成果:
- 58%的结肠直肠癌 (CRC) 病例涉及通过西格莫显微镜可见的瘤.
- 在50岁以下的男性和亚洲或太平洋岛民种族的患者中,瘤更有可能通过半导体镜可见.
- 对于局部性疾病,瘤可见或不可见的生存率相似;然而,对于区域性和转移性癌症,可见的瘤显示出更好的生存率.
结论:
- 大多数结肠直肠癌 (CRC) 发生在可通过柔性晶体镜检测的位置.
- 灵活的半导体镜为CRC查提供了一个可行的选择,特别是对于年轻人群中无法或不愿接受结肠镜检查的人群.
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