使用磁基因基因疗法对运动电路的双向调节 简要: 运动电路的磁基因调节
Santiago R Unda1, Lisa E Pomeranz2, Roberta Marongiu1
1Laboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, Cornell University; New York, NY, USA.
bioRxiv : the preprint server for biology
|July 28, 2023
概括
研究人员开发了新的磁遗传工具,以使用磁场控制神经元活动. 这些工具允许在体内对特定大脑电路进行非侵入性的双向调节.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 遗传学 遗传学 是一个
背景情况:
- 开发非侵入性方法来精确控制神经元活动对于理解大脑功能和治疗神经系统疾病至关重要.
- 磁遗传学提供了一个有前途的途径,通过使用磁场来实现对转基因神经元的远程控制.
结论:
- 这项研究提出了一套新的磁遗传工具,用于精确,非侵入性和双向控制神经元电路.
- 开发的工具在神经科学研究和神经疾病新疗法开发中具有潜在的应用.
- 磁遗传学利用临床上可用的设备,为未来的大脑研究和治疗干预提供了一个强大的平台.
更多相关视频
相关概念视频
Hierarchy of Motor Control
2.9K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.9K
Enteric Nervous System: Regulation of GI Motor Activity
465
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
465
Force On A Current Loop In A Magnetic Field
3.3K
Magnetic forces on wires carrying current are most frequently applied in motors. A DC motor is a device that converts electrical energy into mechanical work. In motors, wire loops are enclosed in a magnetic field. When current flows through the loops, the magnetic field applies torque, which causes the shaft to rotate. The direction of the current is reversed once the loop's surface area is lined up with the magnetic field, causing a constant torque on the loop. During the process,...
3.3K
Magnetism
6.4K
Magnets are commonly found in everyday objects, such as toys, hangers, elevators, doorbells, and computer devices. Experimentation on these magnets shows that all magnets have two poles: one is labeled north (N) and the other south (S). Magnetic poles repel if they are alike and attract if unlike. Moreover, both poles of a magnet attract unmagnetized pieces of iron.
An individual magnetic pole cannot be isolated. No matter how small, every piece of a magnet contains a north pole and a south...
An individual magnetic pole cannot be isolated. No matter how small, every piece of a magnet contains a north pole and a south...
6.4K
Direct Motor Pathways
2.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.1K
Motor Unit Stimulation
1.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
1.7K


