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Updated: May 5, 2026

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
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Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

Published on: August 10, 2014

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改变的GM1代谢会影响ER-PM结处NMDAR介导的Ca2+信号传递,并增加突触脊柱的形成

Jason A Weesner, Ida Annunziata, Diantha van de Vlekkert

    bioRxiv : the preprint server for biology
    |July 28, 2023
    PubMed
    概括

    甘氨基脂GM1对于神经元 (Ca2+) 信号在ER-PM结处至关重要. 它在GM1-型化症中的积累破坏了Ca2+的稳态,改变了突触可塑性并恶化了神经退行.

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