概括

TERT促进器突变 (TPM) 与老化和骨中较短的端粒有关,绕过复制性衰老. BRAF V600E突变引发了瘤基因诱导的衰老,这表明黑色素瘤的发展有不同的途径.

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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