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光动力疗法诱导的细胞循环停止和癌细胞同步:综述

Kave Moloudi¹, Heidi Abrahamse¹, Blassan P George¹

¹Laser Research Centre (LRC) Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.

Frontiers in oncology

|July 28, 2023

概括

光动力疗法 (PDT) 在癌细胞中诱导细胞循环停止 (CCA),提供了一个有前途的治疗策略. 这篇评论探讨了PDT.

科学领域:

在瘤学瘤学.
摄影化学的使用.
细胞生物学细胞生物学

背景情况:

细胞循环停止 (CCA) 是癌症治疗中的一个关键机制,其目标是放射 (RT) 和化疗 (CT) 等治疗方法.
已知光动力疗法 (PDT) 诱导了CCA,但其潜在的机制和由此产生的细胞死亡途径尚不清楚.
PDT的有效性受到氧气,瘤微环境,光特性和光敏感剂 (PS) 属性等因素的影响,需要进一步调查.

研究的目的:

在各种光敏感剂和细胞系中审查PDT诱导的CCA.
阐明PDT诱导的CCA和相关细胞死亡的不清楚机制.
提出反应性氧物种 (ROS) 和它们在PDT中的生物效应的数学模型.

主要方法:

对PDT诱导的CCA的体外和体内研究的文献综述.
分析影响PDT疗效的因素,包括光敏剂和微环境条件.
开发数学模型以将ROS水平与生物结果相关联.

主要成果:

在各种癌症细胞系中,PDT有效地诱导了CCA,提供了一个重要的治疗途径.
在PDT后观察到多种细胞死亡模式,包括非传统类型.
提出了数学模型,以了解ROS生产与生物后果之间的关系.

结论:

PDT诱导的CCA是一种显著的效应,可以指导PDT协议的优化.
标准化,增强和定制PDT方法对于增强癌症治疗至关重要.
对PDT机制和影响因素的进一步研究将改善其临床应用.

关键词:

这就是ROSOS ROS.癌症治疗疗法癌症治疗细胞循环停止细胞循环停止数学模型是指数学模型.光动力学疗法是一种光动力学疗法.摄影敏感剂摄影敏感剂

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