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移植后夫妇的成功怀孕:四个案例报告
Hao Huang1, Xinyu Liu2,3,4, Xiaoli Lin2,3,4
1Department of Rehabilitation Medicine, Renji College of Wenzhou Medical University, Wenzhou, China.
Frontiers in immunology
|July 28, 2023
概括
对于双方都是移植受体的夫妇来说,成功怀孕是可能的. 然而,应该监测诸如不孕不育,早产和低出生体重等风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 由于移植护理的进步,女性移植患者的生育率正在上升.
- 在移植后的夫妇中,评估母亲和新生儿的临床结果至关重要.
研究的目的:
- 评估母亲和新生儿的临床预后,在夫妇中,双方都是移植接受者.
- 确定移植后与怀孕相关的潜在风险和成功结果.
主要方法:
- 对四对夫妇 (全部是脏移植接受者) 的回顾性分析,他们接受了怀孕前评估和随后的怀孕.
- 数据收集包括孕妇和新生儿的临床状况以及整个怀孕期间和产后12个月的实验室结果.
主要成果:
- 怀孕时母亲的平均年龄为34.8岁,移植后的平均年龄为6.6岁.
- 所有分娩都是剖腹产;四分之三的分娩导致过早分娩 (平均35.1周).
- 在体外受精妊娠中发生了一例子宫前,与胎儿体重降低和免疫标记物 (NK,IFN-γ,Treg,IL-10) 改变有关. 母亲的eGFR在怀孕期间波动,但在分娩后基本恢复.
结论:
- 对于接受脏移植的夫妇来说,怀孕是可以实现的,但会带来更大的风险.
- 潜在的并发症包括不育,早产和低出生体重,需要仔细监测.
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