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在结性脊髓炎中血清DKK-1水平:从元分析和孟德尔随机化中的见解
Xi Fang1,2, Cong Chen1,2, Zhi-Xin Wang3
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Frontiers in immunology
|July 28, 2023
概括
在结性脊髓炎 (AS) 患者和健康人群之间,血清Dickkopf-1 (DKK-1) 水平没有显著差异. 此外,DKK-1似乎与发展AS的风险没有因果关系.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 化脊柱炎 (AS) 是一种慢性炎症性疾病,主要影响轴骨架.
- Dickkopf-1 (DKK-1) 是一种参与Wnt信号传递的蛋白质,在骨代谢和炎症中起作用.
- DKK-1在AS病变发生过程中的作用尚不清楚.
研究的目的:
- 为了精确评估与健康对照组相比,结性脊髓炎 (AS) 患者的Dickkopf-1 (DKK-1) 血清水平.
- 调查血清DKK-1水平与发展AS的风险之间的潜在因果关系.
主要方法:
- 对40项涉及2371名AS患者和1633名健康对照者的研究进行了全面的元分析.
- 孟德尔随机化 (MR) 分析被用来评估DKK-1和AS风险之间的因果关系.
- 使用各种统计模型计算了具有95%置信区间 (CI) 的标准化平均差异 (SMD) 和几率比率 (OR).
主要成果:
- 整体元分析显示,AS患者和健康对照人群之间血清DKK-1水平没有显著差异 (SMD=0.207,P=0.516).
- 在CRP≤10mg/L的患者中,亚组分析显示AS患者的DKK-1水平升高 (SMD=2.267,P=0.040).
- MR 分析表明,血清 DKK-1 水平与AS 风险之间没有显著的关联 (IVW OR=0.999,P=0.800).
结论:
- 血清DKK-1度在AS患者和健康对照人群之间没有显著差异.
- 没有证据支持血清DKK-1水平与结性脊髓炎风险之间的因果关系.
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