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具有双重抗菌作用的生物矿物质结合脂质体,用于预防和治疗牙

Zhongling Luo^1,2, Yan Lin¹, Xiaoling Zhou¹

¹Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. liuzb@swmu.edu.cn.

Biomaterials science

|July 28, 2023

概括

新的脂质体有效地提供磁诺醇和可纳来对抗牙损伤. 这种双重药物系统克服了药物疏水性,在体外和体内表现出对关键口腔病原体增强的抗菌活性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
口腔微生物学口腔微生物学

背景情况:

牙损是由于口腔中的病原性因素导致的去矿化造成的.
马格诺洛 (Mag) 和可纳 (FLC) 具有抗菌性,但受性限制.
需要一种新的输送系统来增强Mag和FLC在空治疗中的临床应用.

研究的目的:

开发与Mag和FLC (PPi-Mag/FLC-LPs) 共同装载的生物矿物结合性脂质体.
在酸性腐烂微环境中克服疏水性并实现双重抗菌活性.
在体外和体内评估PPi-Mag/FLC-LP的疗效.

主要方法:

使用激光粒子大小分析,TEM和HPLC进行了PPi-Mag/FLC-LP的特征.
在体外通过光显微镜和HPLC评估了Hydroxyapatite的结合.
通过测量对酸性,抗酸性,生物膜形成和生存的影响来评估对Candida albicans和Streptococcus mutans的抗菌活性.
在活体中,药理动力学被评估在老鼠虫模型中.

主要成果:

PPi-Mag/FLC-LPs显示了对pH敏感的Mag和FLC的释放.
脂质体有效地与氧酸结合.
与单药脂质体或免费药物相比,观察到对C. albicans和S. mutans的增强抗菌作用.
在体内研究显示出良好的抗菌活性.

结论:

PPi-Mag/FLC-LPs可以提高Mag和FLC的药用特性.
该系统提供了快速,pH值敏感的药物释放和有效的酸结合.
PPi-Mag/FLC-LPs显示出作为一种双重药物输送系统的承诺,用于预防和治疗牙损伤.

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