淋巴细胞和乙氨基酸与COVID-19严重程度有关:一项大型回顾性研究
Dildar Duman1, Zuhal Karakurt2, Nagihan Durmuş Koçak1
1Department of Pulmonology, University of Health Sciences, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.
Thoracic research and practice
|July 28, 2023
概括
在COVID-19患者中,低淋巴细胞计数和百分比预测严重疾病和重症监护室入院. 这些生物标志物可以帮助医生更早地管理2019年新冠肺炎疾病.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 新型冠状病毒疾病2019 (COVID-19) 是一个重大的全球健康挑战,患病率和死亡率很高.
- 了解COVID-19严重程度的预测因素对于及时有效的患者管理至关重要.
研究的目的:
- 调查人口统计因素,淋巴细胞水平和乙素水平与COVID-19在入院时的严重程度之间的关联.
- 确定可靠的生物标志物,以预测COVID-19患者需要进入重症监护室 (ICU) 的需要.
主要方法:
- 一项回顾性观察性研究包括5828名COVID-19患者,按严重程度分类 (门诊,住院,重症).
- 分析了人口统计数据和血液图值 (淋巴细胞和乙酸细胞数量/百分比).
- 使用接收器操作特征 (ROC) 曲线和后勤回归来评估严重程度和ICU需求的预测值.
主要成果:
- 淋巴细胞数量和百分比在严重程度组之间有显著差异,而异于异氨基酸水平.
- 特定的临界值为淋巴细胞 (计数<1.0 × 10^9/L,百分比<22%) 和乙素 (百分比<0.08%) 被确定为ICU入院的高风险指标.
- 55岁以上的COVID-19患者的淋巴细胞数量/百分比较低和氨基酸百分比较低,面临需要ICU管理的风险增加了一倍.
结论:
- 淋巴细胞数量和百分比作为预测COVID-19严重性的快速和可靠的生物标志物.
- 这些血液学标记可以帮助临床医生更早,更适当地为COVID-19患者制定管理策略.
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:27Disorders of Leukocytes
983
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
983