东欧艾滋病毒感染者结核病后的长期结果
Christian Kraef1,2,3, Adrian Bentzon1, Ashley Roen1,4
1Centre of Excellence for Health, Immunity and Infections, and.
AIDS (London, England)
|July 28, 2023
概括
结核病 (TB) /艾滋病毒共感染仍然是东欧地区的一个重大挑战,结核病复发率和死亡率很高. 这项研究强调,迫切需要改善对共感染患者的管理策略.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 东欧面临着巨大的结核病 (TB) 和艾滋病毒共感染的负担.
- 在共感染个体中,在结核病诊断后不久观察到高死亡率.
- 这项研究调查了该地区结核病/艾滋病毒患者的长期结果.
研究的目的:
- 评估东欧结核病/艾滋病毒患者的结核病复发率.
- 确定结核病诊断后11年内该人口的死亡率和死亡原因.
- 确定与长期死亡率相关的风险因素.
主要方法:
- 一项纵向队列研究从2011-2013年至2021年跟踪了375名结核病/艾滋病毒患者.
- 竞争风险回归分析了结核病复发,死亡作为竞争事件.
- 卡普兰-梅尔估计和考克斯回归评估了死亡率和风险因素; 编码HIV死亡原因 (CoDe) 方法用于死亡原因判断.
主要成果:
- 共有53名患者 (14.1%) 经历了结核病复发 (3.1/100 PYFU).
- 多药耐药结核病 (MDR-TB) 在复发病例 (69.7%) 中普遍存在.
- 总死亡率为57.3% (11.4/100 PYFU),近一半的死亡归因于结核病,特别是在前24个月的随访期间.
结论:
- 在东欧的艾滋病毒感染者中,结核病复发率和与结核病相关的死亡率仍然非常高.
- 这些结果代表了持续的临床和公共卫生挑战.
- 有效的干预措施至关重要,以减轻该地区结核病/艾滋病毒共感染的影响.
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