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Junsheng Jiang¹, Yueyan Mao¹, Jiabo Wu¹

¹Department of Pediatrics, Linping Branch of the Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

The Journal of international medical research

|July 28, 2023

概括

血液学参数如中性粒细胞与淋巴细胞比率 (NLR),血小板计数 (PLT) 和血小板质量指数 (PMI) 在第一天可以预测早产婴儿的支气管肺功能失调 (BPD) 风险. 较高的NLR和较低的PLT/PMI表明BPD风险增加.

科学领域:

新生儿医学新生儿医学
儿科血液学儿科血液学
呼吸系统医学呼吸系统医学

背景情况:

支气管肺功能障碍症 (BPD) 是早产婴儿的一个重大并发症.
早期识别BPD风险因素对于及时干预至关重要.

研究的目的:

研究生命早期血液学参数与早产新生儿BPD发展之间的关联.
为了确定特定的血液学标记,可以预测BPD风险.

主要方法:

在新生儿重症监护病房 (新生儿重症监护病房) 住院的早产婴儿的回顾性分析 (2017年1月 - 2022年6月).
经过28天以上的缺氧暴露后,诊断出BPD.
在BPD和非BPD组之间比较中性细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),血小板计数 (PLT),平均血小板体积 (MPV) 和血小板质量指数 (PMI).
多变量逻辑回归和接收器操作特征 (ROC) 曲线分析.

主要成果:

包括124名早产婴儿 (48名患有BPD,76名没有).
患有BPD的婴儿的妊娠年龄和体重较低.
在BPD组中观察到显著更高的NLR,MPV和PLR,以及较低的PLT和PMI.
NLR,PLT和PMI被确定为BPD的独立风险因素.
NLR,PLT和PMI显示了BPD可靠的预测价值.

结论:

生后第一天中性粒细胞与淋巴细胞比率 (NLR) 升高,血小板数 (PLT) 和血小板质量指数 (PMI) 降低与患BPD的风险增加有关.
这些血液学参数显示出在早产婴儿中BPD风险分层的早期生物标志物的潜力.

关键词:

中性粒细胞与淋巴细胞的比率.支气管肺功能失育症支气管肺功能失育症血液学参数血液学参数血小板计数血小板计数血小板计数血小板计数血小板质量指数是指血小板质量指数.过早出生的婴儿早产婴儿

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