在健康的非肥胖的韩国成年人中,LEPR基因型和肠道微生物组之间的关联
Yoon Jung Cha1,2, In Ae Chang1, Eun-Heui Jin3
1Clinical Trials Center, Chungnam National University Hospital, Daejeon 35015, Republic of Korea.
Biomolecules & therapeutics
|July 28, 2023
概括
瘦素受体 (LEPR) 基因型可能会影响肠道微生物组合,即使在非肥胖个体中. 一种特定的LEPR多态 (rs1137101) 与韩国成年人中较高水平的Candidatus Saccharibacteria有关.
科学领域:
- 人类遗传学 人类遗传学
- 微生物组研究 微生物组研究
- 代谢健康 代谢健康
背景情况:
- 瘦素受体 (LEPR) 基因型是与肥胖相关的已知因素.
- 肠道微生物组的组成在肥胖和非肥胖个体之间有很大差异.
- 对LEPR基因型对人类肠道微生物组合的直接影响仍未得到充分研究.
研究的目的:
- 调查LEPR单核酸多态 (SNPs) 与非肥胖的韩国成年人肠道微生物组组成之间的关联.
- 探索LEPR基因型,宿主代谢参数和肠道微生物特征之间的潜在相关性.
主要方法:
- 在65名非肥胖的韩国成年人中分析了三个LEPRSNP (rs1173100,rs1137101,rs790419).
- 肠道微生物组的组成是通过16SrRNA测序在类级确定.
- 测量了瘦素,甘油三,LDL胆固醇和HDL胆固醇的水平.
主要成果:
- 在LEPR rs1137101基因型 (G/A与G/G) 之间观察到Candidatus Saccharibacteria相对丰度的显著差异,G/A组的水平更高 (p=0.0322).
- 在rs1137101 G/G和G/A基因组之间没有发现BMI,素或脂质配置文件的显著差异.
- 相对丰富的Fusobacteria和Tenericutes显示出与血瘦素度的显著正相关性 (分别为p=0.0036和p=0.0000).
结论:
- 即使在正常体重的个体中,LEPR基因型也可能与肠道微生物组合有关.
- 需要对包括肥胖成年人在内的更大群体进行进一步的研究,以证实这些发现,并阐明LEPR在塑造肠道微生物群中的作用.
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