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与炎症性肠道疾病相关的自身免疫胰腺炎:在中国进行的一项回顾性双向病例控制研究
Zi Qing Yu1, Xiao Yin Bai1, Ge Chong Ruan1
1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Journal of digestive diseases
|July 28, 2023
概括
在中国,自身免疫性胰腺炎 (AIP) 和炎症性肠病 (IBD) 经常同时发生. IBD患者患有AIP的风险增加,反之亦然,特定的相关因素已被确定.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 自身免疫性胰腺炎 (AIP) 是一种罕见的免疫媒介疾病.
- 炎症性肠病 (IBD) 包括消化道的慢性炎症状况.
- 在中国,AIP和IBD的同时发生和特征仍未得到充分研究.
研究的目的:
- 调查中国AIP和IBD患者的患病率和特征.
- 确定与AIP和IBD同时发生相关的因素.
- 为了比较IBD患者与普通人群发展AIP的风险,反之亦然.
主要方法:
- 采用了一个追溯的,双向的病例控制研究设计.
- 根据已确定的国际指南,IBD和AIP的诊断得到了确认.
- 根据对照组的年龄,性别和疾病类型,患者被匹配.
主要成果:
- 在IBD人群中,AIP-IBD患者的患病率为每10万人中292.0,在AIP人群中为每10万人中8151.93.
- IBD患者的AIP风险显著增加 (OR 8.4),AIP患者的IBD风险增加.
- 梅萨拉明使用和结核感染与IBD患者的AIP相关;便隐性血液检测与AIP患者的IBD相关.
结论:
- 性结肠炎和2型AIP在同时发生的病例中最常见.
- 在中国人群中证实IBD和AIP之间的双向风险增加.
- 特定的临床因素,如梅萨拉明使用,结核病和便隐性血液检测结果与这些条件的同时发生有关.
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