非转移性常规尾骨肉瘤的化疗方案:基于结果的文献综述
Joaquim Soares do Brito1, Rodrigo Santos2, Marco Sarmento3
1Centro Hospitalar Universitário Lisboa Norte, 1649-035 Lisbon, Portugal.
Current oncology (Toronto, Ont.)
|July 28, 2023
概括
手术前的新辅助化疗与尾骨髓瘤手术后的辅助化疗相比,没有显著的生存或毒性益处. 这次审查建议重新评估当前的治疗方案,以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨肉瘤治疗通常包括新辅助化疗,手术和巩固化疗.
- 新辅助化疗对辅助化疗对骨髓瘤的优越性仍然没有得到科学证明.
- 尾非转移性骨肉瘤需要评估化疗时间策略.
研究的目的:
- 为了比较新辅助化疗与辅助化疗在尾性非转移性骨髓瘤中的结果和毒性.
- 评估不同化疗方案在手术前或手术后的疗效.
主要方法:
- 1980年至2020年间发表在MEDLINE/PubMed和Scopus的研究的系统综述.
- 根据标题/摘要选了1254篇文章,预先选择了146篇进行全面审查,并选择了24篇研究 (10篇前性,14篇后性).
- 根据与手术相关的治疗时间将患者分为新辅助化疗 (NAC) 和辅助化疗 (ACT) 组.
主要成果:
- 在NAC和ACT组之间没有观察到总生存率,无病生存率或无事件生存率的显著差异.
- 新辅助和辅助化疗策略之间的毒性概况是可比的.
- 群体之间人口大小的显著差异以及缺乏对临床表现,瘤特征或组织学的考虑.
结论:
- 目前的证据不支持新辅助化疗对尾性非转移性骨髓瘤的辅助化疗的显著优势.
- 研究结果表明,需要重新评估标准治疗方案,以优化患者的生存率,并最大限度地减少并发症.
- 进一步的研究应该考虑患者和瘤特定的变量,以改进化疗时间和提高治疗疗效.
相关概念视频
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Survival Analysis
386
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
386
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


