在加拿大大型集中式CLL诊所的临床结果,基于十年来治疗和分子因素
Jiayu Yang1, Lin Yang1, Bryan Tordon1
1Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P4, Canada.
Current oncology (Toronto, Ont.)
|July 28, 2023
概括
分子测试和慢性淋巴细胞白血病国际预后指数 (CLL-IPI) 对于预测慢性淋巴细胞白血病 (CLL) 的结果至关重要. 这项研究强调了它们在指导治疗和改善加拿大的患者存活率方面的重要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 预后标志物如FISH细胞遗传学,TP53测序和IGHV突变状态在慢性淋巴细胞白血病 (CLL) 中至关重要.
- 这些标志物是CLL国际预后指数 (CLL-IPI) 的组成部分,并指导向治疗选择.
- 这些标记物的常规分子测试在加拿大并不广泛,限制了它们的临床应用.
研究的目的:
- 评估加拿大的CLL患者长期临床结果和生存率.
- 评估分子测试和CLL-IPI得分对患者结局的影响.
- 分析加拿大CLL队列中的治疗模式和新药的有效性.
主要方法:
- 对1315名在1960年至2018年期间被诊断为CLL患者的回顾性分析.
- 包括411名患者的分子测试数据 (FISH,TP53,IGHV) 和233名患者的CLL-IPI得分.
- 12年的随访期,以评估临床结果,治疗和生存率.
主要成果:
- 高风险的FISH和CLL-IPI得分与死亡率的增加显著相关.
- 使用布鲁顿的氨酸激酶抑制剂改善了特定遗传异常 (不变异的IGHV和/或TP53) 患者的生存率.
- 与治疗/疾病相关的原因和二次恶性瘤分别是治疗和未经治疗的患者的主要死亡原因.
结论:
- 分子测试对于确定慢性淋巴细胞白血病的存活率至关重要.
- CLL-IPI得分有效地分层风险,并预测CLL患者的死亡率.
- 向疗法,特别是BTK抑制剂,在提高高风险CLL患者的存活率方面表现出有效性.
更多相关视频
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Survival Analysis
386
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
386


