基于相位逆转的多西环林酸盐结合的玻利在位凝用于牙周炎治疗
Nutdanai Lertsuphotvanit1, Sarun Tuntarawongsa2,3, Takron Chantadee3,4
1Program of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom 73000, Thailand.
Gels (Basel, Switzerland)
|July 28, 2023
概括
这项研究开发了一种新型的在位形成凝 (ISG),使用醇和三氨酸延长多西环林酸释放. 优化的ISG证明了有效治疗牙周炎的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 牙周病学 牙周病学
背景情况:
- 玻利是用于in situ形成凝 (ISG) 的成熟凝剂.
- 从ISG中延长药物释放是理想的,特别是在疏水性添加剂中.
- 酸多西环素 (Dox) 是治疗牙周炎的关键抗生素.
研究的目的:
- 开发和描述新型的多克西环素酸盐加载的基于玻利的ISG,其中包括三素.
- 评估三氨酸度对ISG特性和药物释放动力学的影响.
- 评估开发的ISG对牙周炎病原体的抗菌疗效.
主要方法:
- 40%玻利基ISG的配方,在NMP或DMSO中含有不同度的三氨酸.
- 物理化学特性包括密度,粘度,表面张力和可注射性.
- 评估凝形态,水敏感性,药物释放概况和抗菌活性.
主要成果:
- 添加 triacetin 降低了 ISG 的粘度和密度,低的驱逐力表明容易注射.
- 基于NMP的ISG显示出更高的凝牢度,增强了药物释放的控制.
- 使用5%三氨酸的ISG通过Fickian扩散延长了多克斯释放长达10天,并表现出强大的抗菌活性.
结论:
- 基于玻利的ISG与三氨酸提供可调节性质,用于控制药物输送.
- 5%的三氨酸度提供了延长药物释放和疗效的最佳平衡.
- 这种Dox加载的ISG配方显示出作为治疗牙周炎的局部治疗的希望.
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