固体脂质纳米颗粒嵌入水凝作为一个有前途的载体来延缓Levlunomide的刺激
Hawra Mohammed Alhelal1, Sidharth Mehta2, Varsha Kadian2
1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Gels (Basel, Switzerland)
|July 28, 2023
概括
这项研究在水凝中开发了载有勒诺胺的固体脂质纳米颗粒 (SLN),以改善局部输送. LEF-SLN水凝增强了药物的光稳定性,减少了皮肤刺激,为皮肤疾病提供了更好的抗炎治疗.
科学领域:
- 制药纳米技术 制药纳米技术
- 皮肤病学 皮肤病学
- 药物输送系统 药物输送系统
背景情况:
- 莱弗卢诺米德 (LEF) 是一种抗风湿药物,在牛皮和黑色素瘤等皮肤疾病中显示出抗炎作用的潜力.
- 药物稳定性差和皮肤刺激限制局部LEF应用.
- 固体脂质纳米粒子 (SLNs) 提供了一种有前途的方法来克服这些局限性.
研究的目的:
- 开发和表征Leflunomide装载的固体脂质纳米粒子 (LEF-SLNs) 集成到水凝中,以增强局部输送.
- 评估开发的LEF-SLN水凝配方的稳定性,抗炎活性和皮肤安全性.
主要方法:
- 使用微乳液技术制备LEF-SLN.
- 特性包括粒子大小,泽塔潜力,捕获效率,FTIR和XRD.
- 在体外研究中评估了光稳定性,抗炎活性,药物释放动力学 (Korsmeyer-Peppas模型) 和皮肤刺激 (HET-CAM).
主要成果:
- LEF-SLN 呈现出圆形形状,粒子大小为 273.1 nm,泽塔电位为 -0.15 mV.
- 获得了很高的捕获率 (65.25 ± 0.95%) 和药物含量 (93.12 ± 1.72%) 的结果.
- 与纯药物相比,LEF-SLN水凝表现出优越的光稳定性,显著的体外抗炎活性,理想的风湿性质和减少皮肤刺激.
结论:
- LEF-SLN水凝配方有效地提高了药物的光稳定性,并减少了皮肤刺激.
- 开发的系统显示了改善皮肤病应用的勒诺米德局部输送的显著潜力.
- 这种基于纳米技术的方法为克服与局部药物输送相关的挑战提供了可行的策略.
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