聚乙醇) /普卢兰复合水凝作为伤口包裹应用的潜在平台
Ioana-Alexandra Plugariu1, Maria Bercea1, Luiza Madalina Gradinaru1
1"Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Gels (Basel, Switzerland)
|July 28, 2023
概括
有或没有拉波尼特粘土的聚乙醇 (PVA) 和普鲁兰 (PULL) 水凝被开发用于伤口包裹. 最佳组合显示了在伤口部位控制治疗剂释放的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 聚合物化学 聚合物化学
背景情况:
- 水凝是有效的伤口包裹,因为它们的高流体保留率和创造潮湿的愈合环境的能力.
- 聚乙醇 (PVA) 和普鲁兰 (PULL) 是适合水凝形成的生物相容聚合物.
研究的目的:
- 研究由PVA和PULL混合物形成的物理水凝的特性.
- 评估拉波尼特粘土添加对PVA/PULL水凝特性的影响.
- 评估这些水凝在伤口愈合应用中控制药物输送的潜力.
主要方法:
- 使用冷/解方法制备PVA/PULL水凝,重量比例不同.
- 混合水凝通过加入0.5%的拉波尼特RD来合成.
- 描述包括扫描电子显微镜 (SEM),粘弹性属性分析,胀研究和neomycin硫酸盐体外药物释放.
主要成果:
- SEM证实了水凝的多孔内部结构.
- 水凝成分显著影响了粘弹性特性和网络强度.
- 在生理条件下 (37°C,pH 7.4) 胀遵循了准菲克的扩散机制.
- 药物释放动力学最好地描述的是聚合物水凝的Peppas-Sahlin模型和混合聚合物/粘土水凝的Korsmeyer-Peppas模型.
结论:
- PVA/PULL水凝,特别是那些含有40-60%的没有粘土的PULL水凝,具有适合于伤口包应用的特性.
- 这些水凝显示出在生理条件下在伤口部位控制释放治疗剂的潜力.
- 添加拉波尼特粘土改变了药物释放机制,建议量身定制的应用.
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