在心力衰竭患者中,经过12周的监督并发训练后,左心房功能的改善与中程射出小部分:试点研究
Giuseppe Caminiti1,2, Marco Alfonso Perrone3, Valentino D'Antoni2
1Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, 00163 Rome, Italy.
Journal of cardiovascular development and disease
|July 28, 2023
概括
监督并发训练 (SCT) 显著改善了中等射出率心力衰竭 (HFmrEF) 患者的左心房和左心室功能,提高了运动能力和心脏性能.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 心脏康复心脏康复
背景情况:
- 左心房功能障碍是运动不耐受和心力衰竭 (HF) 预后不佳的已知贡献者.
- 运动干预对中等射出率心力衰竭 (HFmrEF) 患者心脏功能的具体影响仍然在很大程度上未被探索.
研究的目的:
- 评估12周监督并发训练 (SCT) 计划对HFmrEF稳定患者左心房 (LA) 功能的影响.
- 为了将SCT的结果与遵循标准家庭运动指南的对照组进行比较.
主要方法:
- 70名稳定的HFmrEF患者被随机分配到SCT组 (3次/周) 或对照组 (CON).
- 评估包括人体工程测试,6分钟步行测试和在基线和12周后进行的心声回声学.
- 组间比较使用差异分析 (ANOVA).
主要成果:
- 与CON组相比,SCT组在人体体测试持续时间 (p<0.0001) 和6分钟步行测试距离 (p=0.004) 中表现出显著更大的改善.
- 在SCT组观察到高峰心房纵向应变 (+29%,p=0.008) 和导管应变 (+34%,p=0.001) 的显著增加,在CON组没有变化.
- 在SCT中,峰值心房收缩应变增加了21% (p=0.002),左心室全球纵向应变也明显改善 (p=0.03) 与对照组相比.
结论:
- 一个为期12周的监督并发训练计划有效地增强了HFmrEF患者的左心房和左心室功能.
- 这些发现表明,SCT可能是一个有益的治疗策略,用于改善心脏力学在这个患者群体.
- 需要进一步的研究来证实这些益处的长期可持续性,并将其转化为改善的临床结果.
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