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相关概念视频

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

18
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
18
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

24
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
24
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

16
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
16
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

20
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
20
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

364
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
364

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相关实验视频

Updated: Jul 21, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

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心脏衰竭中的性别差异:我们知道什么?

Allegra Arata1, Fabrizio Ricci1,2,3, Mohammed Y Khanji2

  • 1Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.

Journal of cardiovascular development and disease
|July 28, 2023
PubMed
概括

男人和女人经历心力衰竭 (HF) 不同,有不同的亚型和危险因素. 这份综述强调了基于性别的HF差异,强调了为改善患者结果而需要量身定制的管理策略.

关键词:
性别医学性别医学性别医学这些指导方针是指导方针.心脏衰竭是因为心脏衰竭.更年期 绝经 绝经怀孕 怀孕 怀孕 怀孕 怀孕在性爱中,性爱是性爱.治疗治疗治疗治疗治疗治疗

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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

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Echocardiographic Assessment of the Right Heart in Mice
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相关实验视频

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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

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Echocardiographic Assessment of the Right Heart in Mice
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Echocardiographic Assessment of the Right Heart in Mice

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科学领域:

  • 心脏病学 心脏病学
  • 基于性别的医学
  • 公共卫生 公共卫生

背景情况:

  • 心力衰竭 (HF) 是一个主要的全球健康问题,具有显著的发病率和死亡率.
  • 虽然终身风险相似,但男性和女性表现出不同的HF亚型患病率 (减少与保存的射出分数).
  • 现有的基于性别的差异在HF风险因素,表现,病理生理学和治疗反应方面尚不完全理解.

研究的目的:

  • 综合审查和分析心力衰竭中的性别特异性.
  • 批判性地检查HF的定义,风险因素和治疗策略,重点关注女性独特的健康方面.
  • 澄清基于性别的高频率药理治疗和设备指示的知识差距和争议.

主要方法:

  • 系统的文献审查和对现有关于心力衰竭性别差异的研究进行批判性分析.
  • 检查流行病学数据,临床试验结果和病理生理机制.
  • 专注于特定的女性相关因素,如怀孕引起的高血压和过早更年期.

主要成果:

  • 在高频风险因素,临床表现,病理生理学和治疗疗效方面存在显著的基于性别的差异.
  • 女性面临着独特的挑战,包括与怀孕引起的高血压和早期更年期相关的风险.
  • 当前的HF指南不充分地解决性别特定的管理建议.

结论:

  • 更深入地了解性别特异性HF对于开发有效的个性化治疗方法至关重要.
  • 解决药理疗法和器械疗法的知识差距对于公平的HF护理至关重要.
  • 在HF管理中推广适应性别的策略对于改善全球患者的治疗结果至关重要.