治疗扩张性心肌病的代谢方法
Roberto Spoladore1, Giuseppe Pinto2, Francesca Daus3
1Department of Cardiology, Heart Failure Clinic, Alessandro Manzoni Hospital, ASST Lecco, 23900 Lecco, Italy.
Journal of cardiovascular development and disease
|July 28, 2023
概括
扩展性心肌病 (DCM) 心力衰竭涉及心脏代谢异常. 本综述探讨了包括SGLT2抑制剂在内的代谢疗法,以优化心脏能量和改善DCM患者的功能.
科学领域:
- 心脏病学 心脏病学
- 代谢医学是一种代谢医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 扩张性心肌病 (DCM) 导致心力衰竭 (HF),心脏代谢受损,能量效率低下.
- 对心脏衰竭的最佳代谢状态仍在争论中,有关葡萄糖与脂肪酸氧化有相互矛盾的证据.
- 以前的小型试验表明代谢药物可以改善HF的左心室 (LV) 功能,但较大的试验缺乏.
研究的目的:
- 为DCM患者确定最佳的代谢疗法.
- 审查直接针对心脏代谢的药物.
- 概述标准HF治疗的辅助代谢效应,重点关注SGLT2抑制剂.
主要方法:
- 对心脏代谢在HF和DCM中的现有文献的综述.
- 对代谢药物 (trimetazidine,ranolazine等) 的试点试验的分析. ) 的情况.
- 检查体和SGLT2抑制剂在HF中的作用.
主要成果:
- 对代谢药物的小型试验显示,对LV功能和能量有潜在的益处.
- 关于是否增加葡萄糖或脂肪酸氧化,存在相互矛盾的数据.
- SGLT2 抑制剂可以改善高血压患者的心脏功能,可能是通过提高体和优化能量代谢.
结论:
- 代谢功能障碍是DCM相关的高频率的一个关键问题.
- 通过调节能量新陈代谢,SGLT2抑制剂显示出改善心脏功能.
- 需要进一步的研究来确定DCM的最佳代谢策略.
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