在接受心血管手术的老年患者中,血 Askorbic 酸水平与术后狂妄之间存在关联:一项前性观察性研究
Yusuke Iizuka1, Koichi Yoshinaga1, Kyosuke Takahashi1
1Department of Anesthesiology and Critical Care Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.
Journal of cardiovascular development and disease
|July 28, 2023
概括
低的术后 Askorbic 酸水平与心肺绕道心脏手术后的妄想有关. 这表明抗氧化剂,如皮酸可能有助于预防老年人手术后的认知障碍.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 生物化学 生物化学
背景情况:
- 痴呆症在心脏手术后的老年患者中很常见,其中包括心肺旁路 (CPB) 手术.
- 在CPB期间因组织低 perfusion 和再 perfusion 损伤而产生的氧化应激与妄想症的发展有关.
- 亚酸是一种强大的抗氧化剂,可以通过减少活性氧物种 (ROS) 来减轻器官损伤.
研究的目的:
- 调查手术前和手术后血 Askorbic 酸水平与患有 CPB 的心血管手术的老年人妄发病率之间的关联.
主要方法:
- 一项前性观察性研究,涉及98名70岁以上的患者,他们接受了CPB的选择性心血管手术.
- 血 Askorbic 酸水平在手术前和手术后被测量.
- 分析了 Askorbic 酸水平与 Delirium 发展之间的关联.
主要成果:
- 在98名患者中,有31名患者患有 Delirium.
- 在狂妄症和非狂妄症组之间,在手术前的血 Askorbic 酸水平上没有显著差异.
- 在患有 Delirium (p=0.037) 的患者中观察到显著较低的术后血 Askorbic 酸水平.
结论:
- 低的术后血 Askorbic 酸水平可能与患有 CPB 的心血管手术的患者患狂妄症的风险增加有关.
- 研究结果表明,阿斯科布酸在治疗或预防术后狂妄症方面可能发挥作用.
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