拉丁美洲的稀有酵母:罕见但有意义的罕见酵母
Óscar Gil1, Juan Camilo Hernández-Pabón1, Bryan Tabares1,2
1Group MICROS Research Incubator, School of Medicine and Health Sciences, Universidad de Rosario, Bogota 111221, Colombia.
Journal of fungi (Basel, Switzerland)
|July 28, 2023
概括
拉丁美洲罕见的酵母菌感染正在增加,Trichosporon asahii是最常见的原因. 这些机会性感染,特别是真菌病,死亡率高,表现出抗真菌耐药性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在免疫功能低下的患者中,罕见酵母引起的全身感染的发生率越来越高.
- 尽管全球认可日益增长,但在拉丁美洲对罕见酵母病流行病学的理解有限.
- 机会性真菌感染对弱势群体构成重大威胁.
研究的目的:
- 审查和分析拉丁美洲罕见酵母菌感染的人口和临床数据.
- 为了确定该地区常见的罕见酵母物种,相关的风险因素和临床结果.
- 为了解拉丁美洲罕见酵母病流行病学做出贡献.
主要方法:
- 来自8个拉丁美洲国家的495例罕见酵母菌感染病例的系统审查和分析.
- 数据收集包括患者人口统计,临床诊断,致病酵母菌种,治疗方法和结果.
- 基于文化的方法是主要的诊断方法.
主要成果:
- 在12个属中确定了32种罕见的酵母物种,其中Trichosporon asahii (49.5%),Rhodotorula mucilaginosa (11.1%),Saccharomyces cerevisiae (7.8%) 是最常见的.
- 病是主要的诊断 (50.3%). 手术和抗生素使用与Trichosporon有关,而中央静脉导管,白血病和癌症与Rhodotorula有关.
- 原始死亡率为40.8%,真菌病和T. asahii感染的风险更高. 发现了抗真菌耐药性.
结论:
- 这份综述强调了拉丁美洲罕见酵母菌感染的重大负担,其中T. asahii是主要的病原体.
- 病和T. asahii感染与死亡率的增加有关,强调需要及时诊断和治疗.
- 这项研究强调了监测和了解该地区罕见酵母的抗真菌耐药性模式的重要性.
关键词:
地质是一种地质.拉丁美洲 拉丁美洲 拉丁美洲罗多托鲁拉 (Rhodotorula) 是一种轮.这是一种Saccharomyces.三子三子三子侵袭性真菌感染 侵袭性真菌感染菌类病菌的发生.稀有酵母是一种稀有酵母.更多相关视频
09:06Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
Published on: March 29, 2024
767
14:53Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol
Published on: October 24, 2016
11.3K
相关概念视频
Microbial Fermentation
82
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
82
Fungal Group Zygomycota
43
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
43
Yeast Signaling
14.7K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.7K
Fungal Phylum Ascomycota
42
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
42
Fungal Phylum Microsporidia
41
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
41
Overview of Fungi
56
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
56
