基于的金属生物材料的工程抗氧化表面
Jithin Vishnu1, Praveenkumar Kesavan2, Balakrishnan Shankar1
1Department of Mechanical Engineering, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana 690525, India.
Journal of functional biomaterials
|July 28, 2023
概括
由制成的骨科植入物可以通过增加活性氧物种 (ROS) 来引起炎症. 探索表面修改以创建抗氧化表面,提高植入成功率.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 材料工程 材料工程 材料工程
背景情况:
- 骨科金属植入物,特别是合金的长期炎症可能导致无菌松动和失败.
- 在骨质疏松症和植入物腐蚀等疾病中,反应性氧物种 (ROS) 活性增加会加剧氧化应激,阻碍愈合和骨重塑.
- 植入物本质上可以增加ROS产量,对愈合级联和骨再生产生负面影响.
研究的目的:
- 审查与基生物材料相关的ROS生成机制.
- 探索表面修改策略,以增强表面的抗氧化特性.
- 强调在骨科植入物设计和表面工程中考虑ROS生成和氧化应激的重要性.
主要方法:
- 在植入物中产生ROS的文献综述.
- 分析ROS代谢途径,包括超氧化离子,基和过氧化的形成.
- 有机和无机表面涂料对抗氧化功能的概述.
主要成果:
- 及其合金涉及到高ROS产量,导致植入周围的氧化应激.
- 使用有机和无机材料的各种表面修饰技术在开发抗氧化表面方面显示出前景.
- 了解ROS代谢对于减轻对金属植入物的不良生物反应至关重要.
结论:
- 解决ROS生成和氧化应激对于改善骨科植入物的临床成功至关重要.
- 具有抗氧化性能的基于的生物材料的表面工程是一种有前途的策略,可以提高生物相容性和骨质整合.
- 未来的研究应该专注于开发有效的抗氧化剂表面修饰,以减少植入物相关的炎症和失败.
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