富含的酸来源于提拉皮亚骨,具有优越的骨质生成潜力
Xiaxin Cao1, Jiaqi Zhu1, Changze Zhang1
1Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
Journal of functional biomaterials
|July 28, 2023
概括
富含的生物陶是用热处理从鱼骨制成的. 这些鱼骨衍生材料显示出用于组织工程应用的增强性质.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 生物矿物化 生物矿物化
背景情况:
- 酸生物陶对于骨再生至关重要.
- 开发具有增强性质的新生物陶是一种正在进行的研究领域.
- 利用鱼骨等自然资源为生物陶生产提供了一种可持续的方法.
研究的目的:
- 从鱼骨中提取和描述富含的酸生物陶.
- 研究渐变热处理对这些生物陶的特性的影响.
- 评估鱼骨衍生生物陶在生物医学应用中的潜力.
主要方法:
- 在600-800°C下对鱼骨进行渐变热处理,以产生鱼骨衍生的酸 (FHA).
- 在900-1200°C下进一步热处理FHA以产生鱼骨双相酸盐 (FBCP).
- 使用X射线衍射进行表征,并分析化学,物理化学,降解和生物特性.
主要成果:
- 成功合成了FHA和FBCP,在更高的温度下增加了FBCP中的β-三酸含量.
- 与商业酸 (CHA) 相比,较小的格子间距证实了替代.
- FHA和FBCP表现出更快的降解率,释放的Mg2+,表现出优异的骨类无氧化物形成,无毒,并且表现出比CHA更好的骨导活性.
结论:
- 提拉皮亚骨是生产富含的酸生物陶 (FHA和FBCP) 的可行来源.
- 梯度热处理有效地控制了这些生物陶的组成和特性.
- 合成的生物陶显示出生物医学应用的重大前景,特别是在组织工程支架中.
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