室内布罗卢齐祖马布和Aflibercept用于治疗多性冠状血管病
Han Joo Cho1, Kyoung Hae Kang1, Wontae Yoon1
1Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea.
概括
布罗卢齐祖马布和阿弗利柏塞特在多性胆道血管病变 (PCV) 中显示出类似的视觉改善. 布罗卢齐祖马布在减少视网膜厚度和促进PCV患者的聚回归方面表现出卓越的疗效.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 多性冠状血管病变 (PCV) 是一种与年龄相关的黄斑变性的一种亚型.
- 内抗血管内皮生长因子 (抗VEGF) 药物是PCV的标准治疗方法.
- 布罗卢齐祖马布和阿弗利伯塞普是常用的抗VEGF疗法,具有不同的特征.
研究的目的:
- 在未接受过治疗的PCV患者中,比较12个月内内勃鲁西祖马布与阿弗利塞普特的有效性.
- 为了评估视力敏度,解剖学变化和两组治疗群体之间的多回归率.
- 在这个队列中评估brolucizumab和aflibercept的安全性.
主要方法:
- 62个未接受过治疗的PCV眼睛 (62名患者) 的回顾性分析.
- 患者每月接受布罗卢齐祖马布或阿弗利塞普特的静脉内注射,持续3个月,随后按需要注射.
- 对12个月最佳校正的视力敏度,中枢视网膜厚度,亚叶冠状腺厚度和多回归率进行比较.
主要成果:
- 在12个月后,布罗卢齐祖马布和阿弗利塞普特组之间在最佳校正视力敏度改善方面没有显著差异.
- 布罗卢齐祖马布组显示,中枢视网膜厚度 (172比147微米) 和亚叶胆道厚度 (51比29微米) 的显著降低.
- 与aflibercept组 (45.0%) 相比,brolucizumab组 (77.3%) 的多回归率更高. 一例 (4.5%) 的无菌眼内炎症 (眼炎) 观察到与brolucizumab.
结论:
- 在12个月内,静脉内勃鲁西祖马布的视觉结果与aflibercept对PCV的视觉结果相似.
- 布罗卢齐祖马布表现出卓越的解剖疗效,其证据是视网膜和胸膜厚度的更大降低以及更高的多回归率.
- 布罗卢齐祖马布是PCV的可行的治疗选择,具有可管理的安全性,尽管需要对眼内炎症保持警.
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